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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsEXP 6480464CTD[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP1A2 protein; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A2 protein; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein; [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A2 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A2 protein]; Oxygen deficiency affects the reaction [CYP1A2 protein results in increased metabolism of aristolochic acid I]; Oxygen inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]PMID:24657529 PMID:26747958 PMID:26845733
Cyp1a2decreases expressionISOCYP1A2 (Homo sapiens)6480464CTDOxygen deficiency results in decreased expression of CYP1A2 mRNAPMID:19695866
Cyp1a2increases activityISOCyp1a2 (Mus musculus)6480464CTDOxygen results in increased activity of CYP1A2 proteinPMID:21745492
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDOxygen results in increased expression of CYP1A2 mRNAPMID:25703676
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of CYP1A2 mRNAPMID:33811995
Cyp1a2increases response to substanceISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 gene mutant form results in increased susceptibility to OxygenPMID:29180065
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[beta-Naphthoflavone results in increased expression of CYP1A2 protein] inhibits the reaction [CYP1A1 gene mutant form results in increased susceptibility to Oxygen]; [beta-Naphthoflavone results in increased expression of CYP1A2 protein] which results in decreased susceptibility to Oxygen; [Quercetin co-treated with Oxygen] results in increased expression of CYP1A2 mRNA; beta-Naphthoflavone promotes the reaction [Oxygen results in increased activity of CYP1A2 protein]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of CYP1A2 mRNA]; Oxygen inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]PMID:21745492 PMID:28201809 PMID:29180065 PMID:29432836
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 gene mutant form results in increased susceptibility to Oxygen] which results in increased expression of NQO1 mRNA; CYP1A2 gene mutant form inhibits the reaction [beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of CYP1A1 mRNA]]; CYP1A2 gene mutant form inhibits the reaction [Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]]; CYP1A2 gene mutant form inhibits the reaction [Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of NQO1 protein]]; Oxygen deficiency affects the reaction [CYP1A2 protein results in increased metabolism of aristolochic acid I]; Oxygen deficiency affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Oxygen deficiency inhibits the reaction [Acetaminophen results in increased expression of CYP1A2 mRNA]; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]PMID:26845733 PMID:29180065 PMID:33811995
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