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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects response to substanceISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 gene polymorphism affects the susceptibility to Toluene 2,4-DiisocyanatePMID:18447907
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of CYP1A1 mRNAPMID:12415424
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of and results in decreased activity of CYP1A1 proteinPMID:12415424
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