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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:64211
Term: 8-Br-cAMP
Definition: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.
Chemical ID: MESH:D015124
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1increases activityEXP 6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 proteinPMID:21126571 PMID:22120136
Cyp19a1increases expressionEXP 6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP19A1 mRNA; 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP19A1 proteinPMID:21126571 PMID:23583632
Cyp19a1multiple interactionsEXP 6480464CTD[vinclozolin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP19A1 mRNA; Atrazine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]; Atrazine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP19A1 mRNA]; bisphenol A inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]; Methoxychlor inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]PMID:22120136 PMID:23583632
Cyp19a1increases activityISOCYP19A1 (Homo sapiens)6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 proteinPMID:10746939 PMID:18815356
Cyp19a1increases expressionISOCYP19A1 (Homo sapiens)6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP19A1 mRNAPMID:18815356 PMID:22120136 PMID:28859905 PMID:30951242
Cyp19a1multiple interactionsISOCyp19a1 (Mus musculus)6480464CTD[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP19A1 mRNAPMID:21610156
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