GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp19a1 | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of CYP19A1 mRNA | PMID:30557709 | Cyp19a1 | increases expression | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of CYP19A1 mRNA; sodium arsenite results in increased expression of CYP19A1 protein | PMID:24068038 PMID:29301061 | Cyp19a1 | increases expression | ISO | Cyp19a1 (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of CYP19A1 mRNA | PMID:17077188 | Cyp19a1 | multiple interactions | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | [[sodium arsenite results in increased phosphorylation of SRC protein] which results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol; [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of CYP19A1 mRNA; [sodium arsenite results in increased expression of and results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol; [sodium arsenite results in increased phosphorylation of SRC protein] which results in increased activity of CYP19A1 protein; CGP 77675 inhibits the reaction [[sodium arsenite results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol]; CGP 77675 inhibits the reaction [sodium arsenite results in increased activity of CYP19A1 protein]; Letrozole inhibits the reaction [[sodium arsenite results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol]; Letrozole inhibits the reaction [sodium arsenite results in increased activity of CYP19A1 protein]; Letrozole inhibits the reaction [sodium arsenite results in increased expression of CYP19A1 mRNA]; sodium arsenite results in increased expression of and results in increased activity of CYP19A1 protein | PMID:24068038 PMID:32197950 PMID:35747940 | | ||||||||||||||||||||||
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