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GENE - TERM ANNOTATION REPORT

RGD ID: 2346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna4
Name: cholinergic receptor nicotinic alpha 4 subunit
Acc ID: GO:0007271
Term: synaptic transmission, cholinergic
Definition: The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:dos, Wikipedia:Cholinergic
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna4 IMP 1358635RGD  
Chrna4acts_upstream_of_or_withinISOChrna4 (Mus musculus)1624291RGDMGI:2158758 PMID:11226318 PMID:11906696

PMID:11226318 PMID:11906696
Chrna4involved_inIBAMGI:87887 or MGI:87888 or PANTHER:PTN000436077 or Chrna4 (Rattus norvegicus) or ZFIN:ZDB-GENE-980526-1371600115GO_CentralGO_REF:0000033

GO_REF:0000033
Chrna4involved_inIEAGO:00154641600115GOCGO_REF:0000108

GO_REF:0000108
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