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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2326
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpa
Name: CCAAT/enhancer binding protein alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpaaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CEBPA mRNAPMID:22298810
Cebpadecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CEBPA mRNAPMID:18796159 PMID:21215274 PMID:34747641
Cebpamultiple interactionsEXP 6480464CTDherbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]; Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]PMID:11133817
Cebpaaffects expressionISOCebpa (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CEBPA mRNAPMID:24058054
Cebpadecreases expressionISOCebpa (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CEBPA mRNA; Tetrachlorodibenzodioxin results in decreased expression of CEBPA proteinPMID:12758056 PMID:14708085 PMID:16615095 PMID:20633992 PMID:26290441
Cebpadecreases expressionISOCEBPA (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CEBPA mRNAPMID:20106945 PMID:21632981 PMID:26238291
Cebpaincreases expressionISOCebpa (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CEBPA mRNAPMID:15034205 PMID:16054899 PMID:17407152 PMID:21846477 PMID:37318321
Cebpaincreases expressionISOCEBPA (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CEBPA mRNAPMID:28011154
Cebpamultiple interactionsISOCebpa (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CEBPA protein]; [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; [Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of CEBPA mRNA; CEBPA protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC2A4 mRNA]; Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA]; SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CEBPA mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [CEBPA protein binds to SLC2A4 promoter]; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of CEBPA mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CEBPA gene]PMID:12758056 PMID:14708085 PMID:15667827 PMID:16054899 PMID:16615095 PMID:17407152 PMID:21762485
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