GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn2a | affects expression | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | Arsenic affects the expression of CDKN2A protein | PMID:17450239 | Cdkn2a | decreases expression | ISO | Cdkn2a (Mus musculus) | 6480464 | CTD | Arsenic results in decreased expression of CDKN2A mRNA; Arsenic results in decreased expression of CDKN2A protein | PMID:22843710 | Cdkn2a | decreases expression | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | Arsenic results in decreased expression of CDKN2A mRNA | PMID:23872714 | Cdkn2a | increases expression | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | Arsenic results in increased expression of CDKN2A mRNA | PMID:12773770 | Cdkn2a | increases methylation | ISO | CDKN2A (Homo sapiens) | 6480464 | CTD | Arsenic results in increased methylation of CDKN2A gene; Arsenic results in increased methylation of CDKN2A promoter; Arsenic results in increased methylation of CDKN2A promoter alternative form | PMID:16251483 PMID:22466225 PMID:23073540 PMID:23872714 PMID:24525453 PMID:25598836 | Cdkn2a | multiple interactions | ISO | Cdkn2a (Mus musculus) | 6480464 | CTD | BMI1 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A mRNA]; BMI1 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A protein]; SUZ12 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A mRNA]; SUZ12 protein promotes the reaction [Arsenic results in decreased expression of CDKN2A protein] | PMID:22843710 | | ||||||||||||||||||||||
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