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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319357
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfatc1
Name: nuclear factor of activated T-cells 1
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfatc1multiple interactionsISONFATC1 (Homo sapiens)6480464CTDNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]PMID:26792726
Nfatc1multiple interactionsISONfatc1 (Mus musculus)6480464CTDNiclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]PMID:28824321
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