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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2302
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scarb1
Name: scavenger receptor class B, member 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scarb1affects expressionEXP 6480464CTDDibutyl Phthalate affects the expression of SCARB1 proteinPMID:21745491
Scarb1decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of SCARB1 mRNA; Dibutyl Phthalate results in decreased expression of SCARB1 proteinPMID:14617579 PMID:15141095 PMID:15987825 PMID:17379624 PMID:17884934 PMID:19560483 PMID:21266533 PMID:21745491 PMID:26472102 PMID:26948521 PMID:27079746 PMID:28528174 PMID:33983380
Scarb1increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of SCARB1 mRNAPMID:18923996 PMID:32497820
Scarb1multiple interactionsEXP 6480464CTDCadmium Chloride inhibits the reaction [Dibutyl Phthalate results in increased expression of SCARB1 mRNA]PMID:32497820
Scarb1decreases expressionISOSCARB1 (Homo sapiens)6480464CTDDibutyl Phthalate results in decreased expression of SCARB1 mRNAPMID:32417575
Scarb1multiple interactionsISOScarb1 (Mus musculus)6480464CTD[dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate] results in increased expression of SCARB1 mRNAPMID:35739735
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