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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDParaquat results in decreased activity of CAT proteinPMID:12180188 PMID:15177642 PMID:17107770 PMID:20553223 PMID:24799198 PMID:24812154 PMID:25169090 PMID:28696894 PMID:28921394 PMID:33592258
Catdecreases expressionEXP 6480464CTDParaquat results in decreased expression of CAT proteinPMID:32020686 PMID:35707280
Catincreases activityEXP 6480464CTDParaquat results in increased activity of CAT proteinPMID:19486935 PMID:20095329 PMID:27993944 PMID:34048864 PMID:34655599
Catincreases expressionEXP 6480464CTDParaquat results in increased expression of CAT mRNA; Paraquat results in increased expression of CAT proteinPMID:10959798 PMID:11325355 PMID:12826488 PMID:15754033 PMID:17935786 PMID:26598004 PMID:29859004
Catmultiple interactionsEXP 6480464CTD[Maneb co-treated with Paraquat] results in increased expression of CAT mRNA; [Mifepristone co-treated with Paraquat] results in decreased activity of CAT protein; [Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of CAT mRNA; [Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; betanin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein]; ginkgolide C inhibits the reaction [Paraquat results in decreased expression of CAT protein]; naringenin inhibits the reaction [Paraquat results in increased activity of CAT protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in decreased activity of CAT protein]; Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of CAT protein]; pirfenidone inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Paraquat results in increased activity of CAT protein]; Unithiol promotes the reaction [Paraquat results in increased activity of CAT protein]; Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of CAT protein]PMID:19486935 PMID:20095329 PMID:20553223 PMID:24376630 PMID:24799198 PMID:24812154 PMID:25169090 PMID:28696894 PMID:28921394 PMID:29859004 PMID:32020686 PMID:34655599 PMID:35707280
Cataffects activityISOCat (Mus musculus)6480464CTDParaquat affects the activity of CAT proteinPMID:26935021
Cataffects response to substanceISOCAT (Homo sapiens)6480464CTDCAT protein affects the susceptibility to ParaquatPMID:11178967
Catdecreases activityISOCAT (Homo sapiens)6480464CTDParaquat results in decreased activity of CAT proteinPMID:22736252 PMID:26649146
Catdecreases activityISOCat (Mus musculus)6480464CTDParaquat results in decreased activity of CAT proteinPMID:16195250 PMID:25461551 PMID:26708779 PMID:28090784 PMID:28480221 PMID:34811946
Catdecreases expressionISOCAT (Homo sapiens)6480464CTDParaquat results in decreased expression of CAT mRNA; Paraquat results in decreased expression of CAT proteinPMID:20883675 PMID:26468117
Catdecreases expressionISOCat (Mus musculus)6480464CTDParaquat results in decreased expression of CAT mRNAPMID:17215068
Catdecreases response to substanceISOCAT (Homo sapiens)6480464CTDCAT protein results in decreased susceptibility to ParaquatPMID:10751631 PMID:10754530
Catdecreases response to substanceISOCat (Mus musculus)6480464CTDCAT protein results in decreased susceptibility to ParaquatPMID:10699569 PMID:15190189
Catincreases activityISOCat (Mus musculus)6480464CTDParaquat results in increased activity of CAT proteinPMID:10699569 PMID:21801858 PMID:29273418
Catincreases expressionISOCAT (Homo sapiens)6480464CTDParaquat results in increased expression of CAT mRNA; Paraquat results in increased expression of CAT proteinPMID:30243747 PMID:8317554 PMID:9169468
Catincreases expressionISOCat (Mus musculus)6480464CTDParaquat results in increased expression of CAT mRNA; Paraquat results in increased expression of CAT proteinPMID:11728812 PMID:18620719 PMID:30744883
Catincreases response to substanceISOCAT (Homo sapiens)6480464CTDCAT protein modified form results in increased susceptibility to Paraquat; CAT protein results in increased susceptibility to ParaquatPMID:10751631 PMID:14759608
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTD[Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; [NR1I2 protein results in decreased activity of CAT protein] which results in increased susceptibility to Paraquat; [Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA; [Plant Extracts co-treated with Paraquat] results in increased expression of CAT mRNA; [SOD1 protein co-treated with CAT protein] results in decreased susceptibility to Paraquat; CAT protein inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]; CAT protein inhibits the reaction [Paraquat results in decreased expression of GCLC protein]; CAT protein inhibits the reaction [Paraquat results in decreased expression of NFE2L2 mRNA]; CAT protein inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [Paraquat results in increased activity of CASP7 protein]; CAT protein inhibits the reaction [Paraquat results in increased activity of ODC1 protein]; CAT protein inhibits the reaction [Paraquat results in increased expression of JUN mRNA]; CAT protein inhibits the reaction [Paraquat results in increased expression of MIR153 mRNA]; Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased expression of CAT mRNA]; IL1A protein promotes the reaction [Paraquat results in increased expression of CAT protein]; IL1B protein promotes the reaction [Paraquat results in increased expression of CAT protein]; Plant Extracts promotes the reaction [Paraquat results in increased expression of CAT mRNA]; TNF protein promotes the reaction [Paraquat results in increased expression of CAT protein]PMID:16195250 PMID:16677106 PMID:21215309 PMID:22486562 PMID:22736252 PMID:23649336 PMID:24141985 PMID:24866057 PMID:30243747 PMID:7662713 PMID:8317554 PMID:9169468
Catmultiple interactionsISOCat (Mus musculus)6480464CTD[Resveratrol co-treated with Tetracyclines] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Dexamethasone inhibits the reaction [Paraquat results in increased activity of CAT protein]; Hydroxylamine inhibits the reaction [CAT protein results in decreased susceptibility to Paraquat]; NFKB1 protein mutant form inhibits the reaction [Paraquat results in increased expression of CAT mRNA]; NFKBIA protein mutant form inhibits the reaction [Paraquat results in increased expression of CAT mRNA]; Oleanolic Acid inhibits the reaction [Paraquat results in increased activity of CAT protein]; pirfenidone inhibits the reaction [Paraquat results in increased activity of CAT protein]; Resveratrol inhibits the reaction [Paraquat results in decreased activity of CAT protein]; SIRT1 protein affects the reaction [Paraquat affects the activity of CAT protein]; ST2825 inhibits the reaction [Paraquat results in decreased activity of CAT protein]; T0901317 inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Tetracyclines inhibits the reaction [Paraquat results in decreased activity of CAT protein]PMID:10699569 PMID:11728812 PMID:21801858 PMID:25461551 PMID:26708779 PMID:26935021 PMID:28090784 PMID:28480221 PMID:29273418 PMID:34811946
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