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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catmultiple interactionsEXP 6480464CTDAmiodarone inhibits the reaction [Indomethacin results in increased activity of CAT protein]PMID:18087811
Catdecreases activityISOCAT (Homo sapiens)6480464CTDAmiodarone results in decreased activity of CAT proteinPMID:34434487
Catdecreases expressionISOCAT (Homo sapiens)6480464CTDAmiodarone results in decreased expression of CAT mRNAPMID:34434487
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDADM2 protein inhibits the reaction [Amiodarone results in decreased activity of CAT protein]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of CAT mRNA]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased activity of CAT protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of CAT mRNA]]PMID:34434487
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