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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDtriptolide results in increased activity of CASP3 proteinPMID:23639586 PMID:26277538
Casp3increases cleavageEXP 6480464CTDtriptolide results in increased cleavage of CASP3 proteinPMID:25169008 PMID:30009776 PMID:30926361 PMID:31557070
Casp3multiple interactionsEXP 6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [triptolide results in increased activity of CASP3 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]PMID:25169008 PMID:26277538 PMID:30009776 PMID:30926361 PMID:31557070
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDtriptolide results in increased activity of CASP3 proteinPMID:15972136 PMID:21640813
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDtriptolide results in increased cleavage of CASP3 proteinPMID:25169008 PMID:30009776 PMID:30836114 PMID:32835833 PMID:36520315 PMID:38735593
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDtriptolide results in increased cleavage of CASP3 proteinPMID:12533674 PMID:36990132
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDtriptolide results in increased expression of CASP3 protein modified formPMID:30394310
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDtriptolide results in increased expression of CASP3 protein modified formPMID:30394310
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form]; bergenin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; CASP3 inhibits the reaction [[triptolide co-treated with FASL protein] results in increased cleavage of XIAP protein]; Estradiol inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; FASL protein promotes the reaction [triptolide results in increased cleavage of and results in increased activity of CASP3 protein]; mitoquinone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein affects the reaction [bergenin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of CASP3 protein modified form]; TRAJ18 protein affects the reaction [triptolide results in increased cleavage of CASP3 protein]; triptolide results in increased cleavage of and results in increased activity of CASP3 protein; triptolide results in increased expression of and results in increased activity of CASP3 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]PMID:26990902 PMID:30009776 PMID:30394310 PMID:30633930 PMID:30836114 PMID:36520315 PMID:37944651 PMID:38735593
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDNFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; TP53 protein affects the reaction [triptolide results in increased cleavage of CASP3 protein]; triptolide results in increased activity of and results in increased cleavage of CASP3 proteinPMID:19233258 PMID:36990132
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