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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:7986
Term: Pentoxifylline
Definition: An oxopurine that has formula C13H18N4O3.
Chemical ID: MESH:D010431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTD[Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Pentoxifylline inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]PMID:37431890
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDPentoxifylline results in increased activity of CASP3 proteinPMID:18851957
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDPentoxifylline inhibits the reaction [Ethanol results in increased activity of CASP3 protein]PMID:16317704
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of CASP3 proteinPMID:33775688
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