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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:75404
Term: tyrphostin AG 1478
Definition: A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Chemical ID: MESH:C101044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDRTKI cpd promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]PMID:19233221
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDRTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP3 mRNA]]PMID:35716406
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]PMID:34724321
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