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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:6736
Term: melittin
Definition: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.
Chemical ID: MESH:D008555
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDMelitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of and results in increased activity of CASP3 protein]; Melitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP3 mRNA]PMID:21354845
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDMelitten results in decreased expression of CASP3 proteinPMID:34375656
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDMelitten results in increased cleavage of CASP3 proteinPMID:37678661
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDMelitten analog results in increased expression of CASP3 mRNA; Melitten analog results in increased expression of CASP3 protein; Melitten results in increased expression of CASP3 protein modified formPMID:22027265 PMID:29387245
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDMelitten inhibits the reaction [TGFB1 protein results in increased cleavage of CASP3 protein]PMID:21871910
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDMelitten results in increased cleavage of and results in increased activity of CASP3 proteinPMID:21456063
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