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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:6030
Term: isoniazide
Definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Chemical ID: MESH:D007538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTD[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CASP3PMID:35835356
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDIsoniazid results in increased activity of CASP3 proteinPMID:20433247
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDIsoniazid results in increased cleavage of CASP3 proteinPMID:28556920 PMID:31332904
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDIsoniazid results in increased expression of CASP3 mRNAPMID:33771660
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]PMID:21419764 PMID:23764483
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDacadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP3 protein]PMID:28556920 PMID:31332904
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