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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:46979
Term: N-acetylsphingosine
Definition: A N-acylsphingosine that has an acetamido group at position 2.
Chemical ID: MESH:C064769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDN-acetylsphingosine results in increased activity of CASP3 proteinPMID:10919278 PMID:28052715
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDN-acetylsphingosine results in increased activity of CASP3 proteinPMID:21259059
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDBCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 proteinPMID:16215670 PMID:33959992
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