Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDCelecoxib inhibits the reaction [aristolochic acid I results in increased cleavage of CASP3 protein]; Celecoxib inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; Celecoxib inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]PMID:24932515 PMID:31628940 PMID:36863539
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDCelecoxib analog results in decreased expression of CASP3 protein; Celecoxib results in decreased expression of CASP3 proteinPMID:19682443
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDCelecoxib results in increased activity of CASP3 proteinPMID:17201140 PMID:17761345
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDCelecoxib results in increased activity of CASP3; Celecoxib results in increased activity of CASP3 proteinPMID:10753955 PMID:12824303 PMID:17466271 PMID:18202791
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDCelecoxib results in increased cleavage of CASP3 proteinPMID:19665451 PMID:20104024
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDCelecoxib results in increased expression of CASP3 proteinPMID:19635192
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP3 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of and results in increased activity of CASP3 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [Celecoxib results in increased cleavage of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; BIRC5 protein inhibits the reaction [Celecoxib results in increased activity of CASP3 protein]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP3 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]; Celecoxib promotes the reaction [Docetaxel results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased activity of and results in increased expression of CASP3 protein]; Celecoxib results in increased activity of and results in increased expression of CASP3 protein; Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein; Docetaxel promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased activity of and results in increased expression of CASP3 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]PMID:15197583 PMID:15499625 PMID:15572759 PMID:15688368 PMID:16123214 PMID:17461495 PMID:17466271 PMID:18172863 PMID:20104024
Go Back to source page   Continue to Ontology report