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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]PMID:29476062 PMID:31332898 PMID:34374793 PMID:35104487
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDChloroquine results in increased activity of CASP3 proteinPMID:11589424
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDChloroquine results in increased cleavage of CASP3 proteinPMID:30482226
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDChloroquine results in increased cleavage of CASP3 proteinPMID:23151917 PMID:28906492 PMID:30482226
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDChloroquine results in increased expression of CASP3 proteinPMID:25266202
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein; [Rotenone co-treated with Chloroquine] results in increased cleavage of CASP3 protein; BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Chloroquine promotes the reaction [Sunitinib results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]PMID:11589424 PMID:24751611 PMID:26847702 PMID:29111403 PMID:29476062 PMID:30482226 PMID:33684387
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; [Chloroquine co-treated with aumolertinib] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with vandetanib] results in increased activity of CASP3 protein; [vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [formosanin C results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]PMID:23151917 PMID:23799852 PMID:25078063 PMID:25987058 PMID:26853465 PMID:27180204 PMID:28219700 PMID:28906492 PMID:30338810 PMID:30465897 PMID:30482226 PMID:30985881 PMID:31676321 PMID:32190974 PMID:32651653 PMID:34219533 PMID:37741534
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