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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased activity of CASP3 proteinPMID:33812015
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased cleavage of CASP3 proteinPMID:35066053 PMID:37044272
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased cleavage of CASP3 proteinPMID:32971237
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of CASP3 mRNA; perfluorooctanoic acid results in increased expression of CASP3 proteinPMID:34765786
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDNFE2L2 gene mutant form promotes the reaction [perfluorooctanoic acid results in increased activity of CASP3 protein]PMID:33812015
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[perfluorooctanoic acid co-treated with Carbenoxolone] results in increased cleavage of CASP3 protein; Tretinoin inhibits the reaction [perfluorooctanoic acid results in increased cleavage of CASP3 protein]PMID:32971237
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