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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:2981
Term: baicalin
Definition: The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.
Chemical ID: MESH:C038044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDbaicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein]PMID:25423838
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDbaicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; baicalin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]PMID:31021006 PMID:34333357 PMID:35088608
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDbaicalin affects the reaction [Rotenone results in decreased activity of CASP3 protein]PMID:36446982
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