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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:29681
Term: surfactin
Definition: Any mixture comprising isoforms of a bacterial cyclic lipopeptide antibiotic produced by various strains of Bacillus subtilis. The isoforms are cyclodepsipeptides containing at least seven amino acid residues. Among the most effective biosurfactants, surfactin can reduce the surface tension of water from 72 to 27 mN/m at a concentration as low as 0.005%.
Chemical ID: MESH:C009365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDsurfactin peptide results in increased expression of CASP3 protein modified formPMID:34850538
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form]; CAT protein inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form]; surfactin peptide results in increased cleavage of and results in increased activity of CASP3 proteinPMID:19954742 PMID:34850538
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