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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases cleavageISOCASP3 (Homo sapiens)127284886RGDcisplatin increases cleavage of CASP3 protein in stomach 
Casp3increases activityEXP 6480464CTDCisplatin results in increased activity of CASP3 proteinPMID:17604343 PMID:19038279 PMID:19152827 PMID:19578154 PMID:20809784 PMID:21044617 PMID:23603837 PMID:24291008 PMID:29216766 PMID:29476062 PMID:33757793
Casp3increases cleavageEXP 6480464CTDCisplatin results in increased cleavage of CASP3 mRNA; Cisplatin results in increased cleavage of CASP3 proteinPMID:23628706 PMID:25184746 PMID:29852128 PMID:30125553 PMID:32565124 PMID:33393703 PMID:33587916 PMID:36006825 PMID:36270770 PMID:36372261 PMID:36800006 PMID:38437957
Casp3increases expressionEXP 6480464CTDCisplatin results in increased expression of CASP3; Cisplatin results in increased expression of CASP3 mRNA; Cisplatin results in increased expression of CASP3 protein; Cisplatin results in increased expression of CASP3 protein modified formPMID:16787641 PMID:20368269 PMID:21525749 PMID:24632086 PMID:26612654 PMID:27616468 PMID:28414026 PMID:28902463 PMID:32565124 PMID:32621855 PMID:33757793 PMID:34569348 PMID:36567042 PMID:37915485
Casp3multiple interactionsEXP 6480464CTD2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; 5,10,15,20-tetrakis(N-methyl-4'-pyridyl)porphyrinato-iron(III) inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; astragaloside A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Carvedilol inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]; Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein; Cisplatin results in increased expression of and results in increased activity of CASP3 protein; CTNNA1 gene affects the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Cisplatin results in increased expression of CASP3]; Eicosanoids analog inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; er-xian decoction inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Estradiol inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; fisetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; formononetin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; HNF1B protein inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 mRNA]; MIR375 mRNA promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; montelukast inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; Ondansetron inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Pravastatin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; rhoifolin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; Roflumilast inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; SB 203580 promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; Sildenafil Citrate inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Silymarin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Sodium Acetate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; tangeretin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Ursolic Acid inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; vanillin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]PMID:15315938 PMID:19038279 PMID:19152827 PMID:19578154 PMID:20368269 PMID:21044617 PMID:23603837 PMID:24291008 PMID:24632086 PMID:24973089 PMID:25184746 PMID:26612654 PMID:27616468 PMID:28119452 PMID:28414026 PMID:28902463 PMID:29216766 PMID:29476062 PMID:29852128 PMID:30842369 PMID:31103702 PMID:32565124 PMID:32621855 PMID:33393703 PMID:33587916 PMID:33757793 PMID:34569348 PMID:36006825 PMID:36372261 PMID:36567042 PMID:36800006 PMID:37915485 PMID:38437957
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDCisplatin results in decreased expression of CASP3 proteinPMID:32762018
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDCisplatin results in increased activity of CASP3 proteinPMID:15983031 PMID:20547441 PMID:21220912 PMID:21526214 PMID:21616140 PMID:21763304 PMID:22147442 PMID:22269388 PMID:29027213 PMID:29476062 PMID:37863467
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDCisplatin results in increased activity of CASP3 proteinPMID:10663630 PMID:12565868 PMID:14512787 PMID:14727531 PMID:15863139 PMID:16009487 PMID:16080519 PMID:16357177 PMID:16803524 PMID:17619073 PMID:18383853 PMID:20106947 PMID:20654585 PMID:20655883 PMID:20802529 PMID:20878076 PMID:21035837 PMID:21052098 PMID:21132272 PMID:21166495 PMID:21266360 PMID:21311599 PMID:21368866 PMID:21372221 PMID:21507255 PMID:21527773 PMID:21641698 PMID:21737676 PMID:21742513 PMID:21801448 PMID:23165153 PMID:23287709 PMID:23747833 PMID:27417252 PMID:28914995 PMID:33554279 PMID:33757793 PMID:35395232 PMID:35622184 PMID:37704181 PMID:37863467 PMID:37987512
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDCisplatin results in increased cleavage of CASP3 proteinPMID:20883750 PMID:21325496 PMID:21616140 PMID:22269388 PMID:23628706 PMID:25043994 PMID:26193055 PMID:28975372 PMID:31153982 PMID:31256211 PMID:31306688 PMID:32428544 PMID:32504734 PMID:32567747 PMID:32856486 PMID:32991863 PMID:34476871 PMID:34533242 PMID:34560070 PMID:34658261 PMID:35219798 PMID:35279909 PMID:35304134 PMID:36372261 PMID:36965608 PMID:37395757 PMID:38490643 PMID:38688426
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDCisplatin results in increased cleavage of CASP3 proteinPMID:15496615 PMID:17021654 PMID:18058806 PMID:18071906 PMID:18483502 PMID:20145152 PMID:20661229 PMID:20947521 PMID:21255191 PMID:21334329 PMID:21618512 PMID:21660965 PMID:23956100 PMID:25770930 PMID:25940438 PMID:27186303 PMID:27234046 PMID:27815112 PMID:28371273 PMID:29471006 PMID:29567272 PMID:29944906 PMID:30452898 PMID:31153982 PMID:31306688 PMID:31645432 PMID:32238696 PMID:32856486 PMID:34126102 PMID:34533242 PMID:34560070 PMID:34687144 PMID:34785303 PMID:35279909 PMID:35525317 PMID:36070022
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDCisplatin results in increased expression of CASP3 mRNA; Cisplatin results in increased expression of CASP3 protein; Cisplatin results in increased expression of CASP3 protein modified formPMID:20510337 PMID:20702592 PMID:20883750 PMID:24676941 PMID:25308879 PMID:25665769 PMID:29454061 PMID:29476062 PMID:34476871 PMID:35367536 PMID:36178099 PMID:36341876 PMID:37179038
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDCisplatin results in increased expression of CASP3 mRNA; Cisplatin results in increased expression of CASP3 protein; Cisplatin results in increased expression of CASP3 protein modified formPMID:16803524 PMID:20623183 PMID:20623264 PMID:20798217 PMID:21274007 PMID:21278888 PMID:24345465 PMID:24563380 PMID:25776512 PMID:25987058 PMID:27594783 PMID:31255669 PMID:32634519 PMID:33554279 PMID:33757793 PMID:34822033 PMID:38462020
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 3-(4-dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]; 8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; [5-aminoisoquinoline co-treated with Cisplatin] results in increased expression of CASP3 protein; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; [Cisplatin co-treated with Vinorelbine] results in increased activity of CASP3 protein; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; [SLC39A8 protein results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein; ABCB1 protein inhibits the reaction [Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; anemoside B4 inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; apelin-13 peptide inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; arachidonyl-2-chloroethylamide inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Aspirin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; ATG7 gene mutant form inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]; ATG7 gene mutant form inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; ATP2A2 protein inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; aucubin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; CARM1 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Carvedilol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Catechin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; CDKN1A protein inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Cisplatin promotes the reaction [Sildenafil Citrate results in increased cleavage of CASP3 protein]; Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein; Cisplatin results in increased cleavage of and results in increased expression of CASP3 protein; Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Colforsin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; erdosteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; IL6 inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Imatinib Mesylate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Inositol inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Isoproterenol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Linagliptin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Luteolin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased expression of CASP3 protein]; madecassoside inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; MAP2K1 protein promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Metoclopramide inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; nutlin 3 inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; PAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; PARK7 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; pevonedistat inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; pevonedistat inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]; PRMT3 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; RAPGEF3 mutant form inhibits the reaction [Isoproterenol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]; Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; rosamultin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Rutin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; salubrinal promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Sildenafil Citrate promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; Sodium Acetate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Streptozocin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; TIMD2 promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]PMID:20510337 PMID:20547441 PMID:20702592 PMID:20883750 PMID:21325496 PMID:21499899 PMID:21526214 PMID:21544650 PMID:21570986 PMID:21593185 PMID:21616140 PMID:21745194 PMID:21763304 PMID:22147442 PMID:22269388 PMID:23770416 PMID:24012798 PMID:24676941 PMID:25043994 PMID:25308879 PMID:25665769 PMID:26193055 PMID:29027213 PMID:29191451 PMID:29454061 PMID:29476062 PMID:30342059 PMID:31153982 PMID:31256211 PMID:31306688 PMID:32428544 PMID:32504734 PMID:32567747 PMID:32856486 PMID:32991863 PMID:34476871 PMID:34533242 PMID:34560070 PMID:34658261 PMID:35219798 PMID:35304134 PMID:35367536 PMID:36178099 PMID:36372261 PMID:36800006 PMID:36965608 PMID:37087747 PMID:37179038 PMID:37395757 PMID:37863467 PMID:38059649 PMID:38490643 PMID:38688426
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD(+)-JQ1 compound promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]; 8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; [3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]] which results in increased cleavage of CASP3 protein; [4-methylene-2-octyl-5-oxofuran-3-carboxylic acid co-treated with Cisplatin] results in increased cleavage of and results in decreased expression of CASP3 protein; [4-methylene-2-octyl-5-oxofuran-3-carboxylic acid co-treated with Cisplatin] results in increased cleavage of and results in increased activity of CASP3 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of CASP3 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of CASP3 protein; [ACE2 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]] which results in decreased cleavage of PARP1 protein; [andrographolide co-treated with Cisplatin] results in increased expression of CASP3 mRNA; [Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [Cisplatin co-treated with Bortezomib] results in increased activity of CASP3 protein; [Cisplatin co-treated with CDKN1A protein] results in increased cleavage of CASP3 protein; [Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein; [Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein; [Cisplatin co-treated with fisetin] results in increased cleavage of and results in increased activity of CASP3 protein; [Cisplatin co-treated with Roflumilast] results in increased expression of CASP3 mRNA; [Cisplatin co-treated with S63845] results in increased cleavage of CASP3 protein; [Cisplatin promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein]] which results in increased cleavage of XIAP protein; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of CASP3 mRNA; [Cisplatin results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein; [CITED2 results in decreased susceptibility to Cisplatin] which results in decreased activity of CASP3 protein; [Fluorouracil co-treated with Cisplatin] results in increased activity of CASP3 protein; [Fluorouracil co-treated with Cisplatin] results in increased expression of CASP3 protein; [GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; [Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP3 mRNA; [Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [Paclitaxel co-treated with Cisplatin] results in increased activity of CASP3 protein; [Quercetin co-treated with Cisplatin] results in increased activity of CASP3 protein; [S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the cleavage of CASP3 protein; [SND1 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of and results in increased activity of CASP3 protein; [TNFSF10 protein co-treated with Cisplatin] results in increased activity of CASP3 protein; [trigonelline co-treated with Cisplatin] results in increased cleavage of CASP3 protein; ABCB1 protein inhibits the reaction [Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein]; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; AKT1 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; BCL2 inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; BCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein]; beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; BMI1 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; calpeptin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; CAPN1 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; CAPN2 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; CAV1 protein promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; CD40LG protein inhibits the reaction [Cisplatin promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; Cisplatin inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [(+)-JQ1 compound results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Cisplatin promotes the reaction [eprenetapopt results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [Metformin results in increased activity of CASP3 protein]; Cisplatin promotes the reaction [Roflumilast results in increased activity of CASP3 protein]; Cisplatin promotes the reaction [Roflumilast results in increased expression of CASP3 mRNA]; Cisplatin promotes the reaction [S63845 results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [SC-66 compound results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein]; Cisplatin results in decreased expression of and results in increased cleavage of CASP3 protein; Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein; Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein; Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein; CITED2 mutant form promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; CXCL8 inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Deferoxamine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; DICER1 mutant form inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; ESR2 protein promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; FAM168A protein inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; GCS-100 promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; GJA1 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; GNAS protein inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Hemin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; HMGN5 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; HSPA5 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; IER5 protein promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; ING4 protein promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; Inositol inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; MAF1 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; MAPK15 protein affects the reaction [TNF protein promotes the reaction [Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein]]; MDM2 protein promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; MIR375 inhibits the reaction [tanshinone II A sodium sulfonate inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]; MIR375 promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; MIR630 mRNA inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; NOTCH1 protein affects the reaction [MDM2 protein promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; oleylamide inhibits the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Oxygen deficiency promotes the reaction [Cisplatin promotes the reaction [eprenetapopt results in increased cleavage of CASP3 protein]]; PD 150606 inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; PD 150606 inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; PLK1 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; PRDX6 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; RAPGEF3 affects the reaction [8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]; RELA protein mutant form inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; RNF34 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Roflumilast promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; rosamultin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; SC-66 compound promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; SLC7A11 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; SND1 mutant form promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; tanshinone II A sodium sulfonate inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; tanshinone II A sodium sulfonate promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein]; TNFSF10 protein promotes the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; TP53 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; TRAF2 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; TRAP1 protein inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Tretinoin promotes the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]; TYMP inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; TYMP protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; USP39 protein inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Valproic Acid promotes the reaction [Cisplatin results in increased activity of CASP3 protein]; YAP1 protein inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]PMID:12565868 PMID:12709826 PMID:14727531 PMID:15496615 PMID:16080519 PMID:16357177 PMID:16545138 PMID:16803524 PMID:17399942 PMID:17574045 PMID:17619073 PMID:17853063 PMID:18058806 PMID:18176112 PMID:18483502 PMID:20106947 PMID:20145152 PMID:20623183 PMID:20623264 PMID:20655883 PMID:20661229 PMID:20674069 PMID:20802529 PMID:20856198 PMID:20947521 PMID:21037225 PMID:21052098 PMID:21166495 PMID:21216935 PMID:21252285 PMID:21255191 PMID:21266360 PMID:21311599 PMID:21334329 PMID:21368866 PMID:21388661 PMID:21418860 PMID:21442130 PMID:21507255 PMID:21618512 PMID:21660965 PMID:21737676 PMID:21742513 PMID:21745194 PMID:22269388 PMID:23251525 PMID:23747833 PMID:24563380 PMID:25770930 PMID:25940438 PMID:25987058 PMID:27186303 PMID:27234046 PMID:27417252 PMID:27514524 PMID:27815112 PMID:28914995 PMID:29471006 PMID:29567272 PMID:29690507 PMID:29944906 PMID:29962303 PMID:30342059 PMID:30452898 PMID:30871063 PMID:31153982 PMID:31306688 PMID:31645432 PMID:32238696 PMID:32800223 PMID:32856486 PMID:33148531 PMID:33757793 PMID:34126102 PMID:34533242 PMID:34560070 PMID:34687144 PMID:34785303 PMID:34822033 PMID:35395232 PMID:35525317 PMID:35622184 PMID:36070022 PMID:36425765 PMID:37659683 PMID:37760451 PMID:37863467 PMID:37987512
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