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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:16509
Term: 1,4-benzoquinone
Definition: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Chemical ID: MESH:C004532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases activityISOCASP3 (Homo sapiens)6480464CTDquinone results in decreased activity of CASP3 proteinPMID:17051661 PMID:22960397
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDquinone results in increased activity of CASP3 proteinPMID:20499891 PMID:32478940
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDquinone analog results in increased expression of CASP3 protein modified formPMID:33961949
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[quinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]PMID:15337166 PMID:33961949
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDCarnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]PMID:32478940
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