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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCASP3 (Homo sapiens)152995489RGDBerberine increases activity of CASP3 protein in colon epithelial cells 
Casp3multiple interactionsEXP 6480464CTD[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 mRNA]; Berberine inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 mRNA]PMID:25600690 PMID:30138605 PMID:33460233 PMID:35439518 PMID:37955270
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDBerberine results in increased activity of CASP3 proteinPMID:20656010
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDBerberine results in increased cleavage of CASP3 proteinPMID:26712469
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDBerberine results in increased expression of CASP3 mRNAPMID:20656010
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDBerberine inhibits the reaction [Particulate Matter results in increased expression of CASP3 protein]PMID:37839514
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein]; Berberine results in increased cleavage of and results in increased activity of CASP3 proteinPMID:16505103 PMID:26712469 PMID:36070022
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