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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:16015
Term: L-glutamic acid
Definition: An optically active form of glutamic acid having L-configuration.
Chemical ID: MESH:D018698
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDGlutamic Acid results in increased expression of CASP3 protein; Glutamic Acid results in increased expression of CASP3 protein modified formPMID:18490855 PMID:35028790
Casp3multiple interactionsEXP 6480464CTDschizandrin inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein modified form]PMID:18490855 PMID:35028790
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDGlutamic Acid results in increased activity of CASP3 proteinPMID:27654887
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDGlutamic Acid results in increased activity of CASP3 proteinPMID:33617922
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDGlutamic Acid results in increased expression of CASP3 proteinPMID:33617922
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDDronabinol inhibits the reaction [Glutamic Acid results in increased activity of CASP3 protein]PMID:27654887
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; dihydroactinidiolide inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein]PMID:24732427 PMID:33617922
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