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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDthymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [nonylphenol results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]PMID:29085585 PMID:29710533 PMID:30558456 PMID:32394736 PMID:34234489 PMID:35437842 PMID:37466128
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDthymoquinone results in increased activity of CASP3 proteinPMID:34605108
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDthymoquinone results in increased cleavage of CASP3 proteinPMID:31298468 PMID:34627931 PMID:36176197
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDthymoquinone results in increased expression of CASP3 protein modified formPMID:31433961 PMID:34173702
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDDoxorubicin promotes the reaction [thymoquinone results in increased activity of CASP3 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CASP3 protein]; thymoquinone promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]PMID:34605108 PMID:36193556
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein; [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of CASP3 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein]; MAPK14 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein]; thymoquinone results in increased activity of and results in increased cleavage of CASP3 proteinPMID:29981725 PMID:31433961 PMID:31935363 PMID:34173702 PMID:34627931 PMID:36176197
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