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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:10043
Term: wogonin
Definition: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.
Chemical ID: MESH:C085514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDwogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein]PMID:31103702
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDwogonin results in increased activity of CASP3 proteinPMID:20570612
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDwogonin results in increased expression of CASP3 mRNAPMID:38134066
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDwogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein]PMID:26756871
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[wogonin co-treated with Fluorouracil] results in increased activity of CASP3 proteinPMID:20570612
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