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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2206
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bglap
Name: bone gamma-carboxyglutamate protein
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bglapdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of BGLAP mRNAPMID:19201780 PMID:19264158
Bglapaffects expressionISOBglap (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of BGLAP mRNAPMID:24680724
Bglapaffects expressionISOBGLAP (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of BGLAP mRNA; Tetrachlorodibenzodioxin affects the expression of BGLAP proteinPMID:30203000 PMID:31887333
Bglapdecreases expressionISOBglap (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of BGLAP; Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNAPMID:19264158 PMID:19367694 PMID:22749964 PMID:25795401 PMID:34363983
Bglapmultiple interactionsISOBglap (Mus musculus)6480464CTDAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]; Tetrachlorodibenzodioxin results in increased expression of and results in increased secretion of BGLAP protein; tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]PMID:19264158 PMID:22749964 PMID:29673856
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