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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:9130
Term: sevoflurane
Definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Chemical ID: MESH:C009250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDSevoflurane results in decreased expression of BCL2 proteinPMID:33171207 PMID:35110470 PMID:35174938
Bcl2multiple interactionsEXP 6480464CTDDietary Fats promotes the reaction [Sevoflurane results in decreased expression of BCL2 protein]; Nimodipine inhibits the reaction [Sevoflurane results in decreased expression of BCL2 protein]PMID:33171207 PMID:35174938
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDSevoflurane results in decreased expression of BCL2 proteinPMID:35472370
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