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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDMetformin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2 mRNA]; Metformin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]PMID:26492952 PMID:26818447 PMID:28106847 PMID:30144576 PMID:34801538 PMID:35414346
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDMetformin results in decreased expression of BCL2 proteinPMID:21388661 PMID:29226720
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Paclitaxel co-treated with Metformin] results in decreased expression of BCL2 mRNA; Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2 protein]PMID:21388661 PMID:29309887
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