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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionEXP 6480464CTDThioacetamide affects the expression of BCL2 proteinPMID:21885874 PMID:34792689
Bcl2increases expressionEXP 6480464CTDThioacetamide results in increased expression of BCL2 mRNAPMID:29133031 PMID:30138605
Bcl2multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]; chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]; chloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]]; Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]; Doxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]]; Quercetin inhibits the reaction [Thioacetamide affects the expression of BCL2 protein modified form]; S100B protein promotes the reaction [Thioacetamide results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]PMID:21885874 PMID:23830814 PMID:29133031 PMID:30138605 PMID:34792689
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[TXNIP gene mutant form co-treated with Thioacetamide] results in increased expression of BCL2 proteinPMID:20713078
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