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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects cleavageISOBcl2 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl affects the cleavage of BCL2 proteinPMID:25659934
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of BCL2 proteinPMID:21291966
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of BCL2 proteinPMID:20638727
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of BCL2 proteinPMID:21291966
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