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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:2979
Term: baicalein
Definition: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Chemical ID: MESH:C006680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDbaicalein results in decreased expression of BCL2 proteinPMID:33838155
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form]; baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]PMID:20850421 PMID:37783230
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDMIR3663 mRNA promotes the reaction [baicalein results in decreased expression of BCL2 protein]PMID:33838155
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