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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDCannabidiol affects the expression of BAX mRNAPMID:38342230
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDCannabidiol results in decreased expression of BAX proteinPMID:27932991
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCannabidiol results in increased expression of BAX mRNA; Cannabidiol results in increased expression of BAX proteinPMID:31349651 PMID:33244087 PMID:34575494 PMID:36810933
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX protein]PMID:36988283
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Cannabidiol co-treated with moringin] results in decreased expression of BAX mRNA; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BAX protein]; iodopravadoline inhibits the reaction [Cannabidiol results in decreased expression of BAX protein]; Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of BAX protein]PMID:27932991 PMID:30096889 PMID:36988283
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