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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of BAX proteinPMID:18602972 PMID:19135049 PMID:19466539 PMID:19524685 PMID:24358303 PMID:27053303 PMID:31430510
Baxmultiple interactionsEXP 6480464CTD[1-Methyl-4-phenylpyridinium results in increased activity of CAPN1 protein] which results in increased localization of BAX protein; Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; benserazide, levodopa drug combination inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; Drugs, Chinese Herbal inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; Drugs, Chinese Herbal inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; ML 9 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; MRS 1845 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; peoniflorin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; STIM1 mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]PMID:18496573 PMID:18602972 PMID:19135049 PMID:19466539 PMID:19524685 PMID:24358303 PMID:27053303 PMID:31430510
Baxaffects expressionISOBAX (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium affects the expression of BAX proteinPMID:29575151
Baxaffects response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein affects the susceptibility to 1-Methyl-4-phenylpyridiniumPMID:18266926
Baxincreases expressionISOBax (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of BAX proteinPMID:12880480 PMID:26300475 PMID:29566083 PMID:34967706 PMID:37741537
Baxincreases expressionISOBAX (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of BAX proteinPMID:17266988 PMID:18266926 PMID:19646423 PMID:20946892 PMID:21295016 PMID:21497157 PMID:22278385 PMID:24399507 PMID:24806433 PMID:25073091 PMID:25968939 PMID:26357513 PMID:26364587 PMID:28187263 PMID:28481321 PMID:28851138 PMID:30463061 PMID:31381935 PMID:32154657 PMID:33069733 PMID:33472166 PMID:34773593 PMID:35279586 PMID:36515797
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDdorsomorphin inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; MIAT affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]PMID:34967706 PMID:37741537
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; 8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo(5,6-g)quinoxaline-7,9-dione inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; ARHGAP26 protein inhibits the reaction [MIR1277 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; atractylenolide I inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; BAX protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; INS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; INS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; KDM7A-DT inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; KPNA4 protein inhibits the reaction [MIR671 mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; MIR1277 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; MIR1277 promotes the reaction [NEAT1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; MIR134 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; MIR134 inhibits the reaction [KDM7A-DT inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; MIR671 affects the reaction [UCA1 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; MIR671 mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; NDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; NDFIP1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; NEAT1 mRNA affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of BAX protein]; NEAT1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; PIK3R3 protein affects the reaction [MIR134 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; Quercetin inhibits the reaction [squamosamide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Rosiglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; SNCA mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; SOS1-IT1 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]; squamosamide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; STUB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; UCA1 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]PMID:17266988 PMID:19646423 PMID:20946892 PMID:21295016 PMID:21497157 PMID:22278385 PMID:24399507 PMID:25073091 PMID:25968939 PMID:26300475 PMID:26357513 PMID:26364587 PMID:28187263 PMID:28481321 PMID:28851138 PMID:29575151 PMID:30463061 PMID:33069733 PMID:33472166 PMID:34773593 PMID:35279586 PMID:36515797
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