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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionISOBax (Mus musculus)6480464CTDsorafenib results in decreased expression of BAX mRNAPMID:21360571
Baxincreases cleavageISOBAX (Homo sapiens)6480464CTDsorafenib results in increased cleavage of BAX proteinPMID:16109713
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDsorafenib results in increased expression of BAX proteinPMID:18200035
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[antrocin analog co-treated with Sorafenib] results in increased expression of BAX protein; [Sorafenib co-treated with TNFSF10 protein] affects the folding of and results in increased activity of BAX protein; [Sorafenib co-treated with TNFSF10 protein] affects the localization of BAX protein; BCL2L1 protein inhibits the reaction [Sorafenib affects the folding of and results in increased activity of BAX protein]; MCL1 protein inhibits the reaction [[Sorafenib co-treated with TNFSF10 protein] affects the folding of and results in increased activity of BAX protein]; Sorafenib affects the folding of and results in increased activity of BAX proteinPMID:17909059 PMID:19366808 PMID:36565974
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