GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | decreases expression | EXP | | 6480464 | CTD | Acetaminophen results in decreased expression of BAX mRNA | PMID:20732408 | Bax | increases expression | EXP | | 6480464 | CTD | Acetaminophen results in increased expression of BAX protein | PMID:11562448 PMID:26767949 PMID:32909844 | Bax | multiple interactions | EXP | | 6480464 | CTD | Fatty Acids, Omega-3 affects the reaction [Acetaminophen results in increased expression of BAX protein]; morin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; Silymarin affects the reaction [Acetaminophen results in increased expression of BAX protein] | PMID:26767949 PMID:32909844 | Bax | affects expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Acetaminophen affects the expression of BAX mRNA | PMID:17562736 | Bax | affects expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Acetaminophen affects the expression of BAX mRNA | PMID:20732408 | Bax | affects localization | ISO | Bax (Mus musculus) | 6480464 | CTD | Acetaminophen affects the localization of BAX protein | PMID:17906064 PMID:20423716 PMID:21241727 PMID:21572097 PMID:24440347 PMID:27562556 PMID:27773698 PMID:29739258 | Bax | affects response to substance | ISO | Bax (Mus musculus) | 6480464 | CTD | BAX protein affects the susceptibility to Acetaminophen | PMID:17906064 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased expression of BAX mRNA; Acetaminophen results in increased expression of BAX protein | PMID:12540782 PMID:20355050 PMID:22939915 PMID:28435131 PMID:30375433 PMID:31697998 PMID:31967706 PMID:33571619 PMID:35166444 PMID:35179299 PMID:36928416 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased expression of BAX mRNA; Acetaminophen results in increased expression of BAX protein | PMID:22230336 PMID:33959992 PMID:33971260 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; coomassie Brilliant Blue inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; Fomepizole inhibits the reaction [Acetaminophen affects the localization of BAX protein]; Irbesartan inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; necrostatin-1 inhibits the reaction [Acetaminophen affects the localization of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of BAX mRNA]; Plant Extracts inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of BAX protein] | PMID:12540782 PMID:20355050 PMID:20423716 PMID:22939915 PMID:24440347 PMID:28435131 PMID:29739258 PMID:31697998 PMID:31967706 PMID:35166444 PMID:35179299 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of BAX mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of BAX protein]; oltipraz inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BAX protein] | PMID:33959992 PMID:33971260 | | ||||||||||||||||||||||
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