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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:38221
Term: fumonisin B1
Definition: A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
Chemical ID: MESH:C056933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionISOBax (Mus musculus)6480464CTDfumonisin B1 affects the expression of BAX mRNAPMID:35697133
Baxincreases expressionISOBax (Mus musculus)6480464CTDfumonisin B1 results in increased expression of BAX proteinPMID:35697133
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDfumonisin B1 results in increased expression of BAX mRNA; fumonisin B1 results in increased expression of BAX proteinPMID:31891755
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX mRNA]PMID:36397609
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[fumonisin B1 results in decreased chemical synthesis of Ceramides] which results in decreased expression of BAX proteinPMID:25195822
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