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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDchromium hexavalent ion results in increased expression of BAX proteinPMID:24530425 PMID:35024197
Baxmultiple interactionsEXP 6480464CTD[Potassium Dichromate results in increased abundance of chromium hexavalent ion] promotes the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of BAX protein]; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX protein; Resveratrol inhibits the reaction [chromium hexavalent ion results in increased expression of BAX protein]PMID:30974164 PMID:35024197 PMID:35307491 PMID:36849043
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDchromium hexavalent ion affects the localization of BAX proteinPMID:16166740
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDchromium hexavalent ion results in increased expression of BAX proteinPMID:29069462
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX mRNA; [sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX protein; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX protein]PMID:35643323
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDTP53 protein affects the reaction [chromium hexavalent ion affects the localization of BAX protein]PMID:16166740
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