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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDGlyphosate results in increased expression of BAX mRNAPMID:33797725
Baxmultiple interactionsEXP 6480464CTD[Surface-Active Agents co-treated with Glyphosate] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [Glyphosate results in increased expression of BAX mRNA]PMID:23099315 PMID:33797725
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDGlyphosate results in decreased expression of BAX proteinPMID:24073338
Baxincreases expressionISOBax (Mus musculus)6480464CTDGlyphosate results in increased expression of BAX mRNA; Glyphosate results in increased expression of BAX proteinPMID:29908847 PMID:30785197 PMID:31352102 PMID:33159990
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDGlyphosate results in increased expression of BAX mRNA; Glyphosate results in increased expression of BAX proteinPMID:30907447 PMID:31295307 PMID:31874349
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDMelatonin inhibits the reaction [Glyphosate results in increased expression of BAX mRNA]; XAF1 protein affects the reaction [Glyphosate results in increased expression of BAX protein]PMID:29908847 PMID:33159990
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of BAX mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of BAX protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BAX mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BAX protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of BAX mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of BAX proteinPMID:32800223
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