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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of BAX mRNAPMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194 PMID:23385219 PMID:27288928 PMID:28442411 PMID:32418920 PMID:33354967
Baxmultiple interactionsEXP 6480464CTD[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]PMID:27288928
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of BAX proteinPMID:20106945
Baxdecreases phosphorylationISOBAX (Homo sapiens)6480464CTDAflatoxin B1 results in decreased phosphorylation of BAX proteinPMID:22743290
Baxincreases expressionISOBax (Mus musculus)6480464CTDAflatoxin B1 results in increased expression of BAX mRNA; Aflatoxin B1 results in increased expression of BAX proteinPMID:30126036 PMID:35304092
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of BAX mRNA; Aflatoxin B1 results in increased expression of BAX proteinPMID:22743290 PMID:27153756 PMID:28943387 PMID:29445054 PMID:34089297
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDAflatoxin B1 inhibits the reaction [Zearalenone results in increased expression of BAX mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of BAX protein]PMID:25445755 PMID:35304092
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