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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionEXP 6480464CTDGlucose affects the expression of BAX proteinPMID:22524206
Baxincreases expressionEXP 6480464CTDGlucose results in increased expression of BAX mRNA; Glucose results in increased expression of BAX proteinPMID:23192364 PMID:26054749 PMID:27234048 PMID:28106847 PMID:28713934 PMID:30144576 PMID:31323227 PMID:33764184 PMID:36462176 PMID:37619648 PMID:38444079
Baxmultiple interactionsEXP 6480464CTD3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Glucose results in increased expression of BAX protein]; [Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein; [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; cinnamic acid inhibits the reaction [Glucose results in increased expression of BAX protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of BAX protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; gastrodin inhibits the reaction [Glucose results in increased expression of BAX protein]; Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; morroniside inhibits the reaction [Glucose results in increased expression of BAX protein]; naringenin inhibits the reaction [Glucose results in increased expression of BAX mRNA]; naringenin inhibits the reaction [Glucose results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein]; Quercetin affects the reaction [Glucose affects the expression of BAX protein]; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]; Scopoletin inhibits the reaction [Glucose results in increased expression of BAX protein]; sesamin affects the reaction [Glucose affects the expression of BAX protein]; STIM1 protein affects the reaction [Glucose results in increased expression of BAX protein]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]PMID:21803128 PMID:22524206 PMID:23192364 PMID:23451161 PMID:25305180 PMID:26054749 PMID:27234048 PMID:28106847 PMID:28713934 PMID:30144576 PMID:31323227 PMID:31935362 PMID:33764184 PMID:37619648
Baxincreases expressionISOBax (Mus musculus)6480464CTDGlucose results in increased expression of BAX proteinPMID:29266779 PMID:31672611 PMID:33764184
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDGlucose results in increased expression of BAX mRNA; Glucose results in increased expression of BAX proteinPMID:24218232 PMID:30431688 PMID:30802477 PMID:31115753 PMID:32602595 PMID:37417536 PMID:38069837 PMID:38124441
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [Isoflurane inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX mRNA]]; 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [Isoflurane inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]]; 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX mRNA]; 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one promotes the reaction [[Glucose co-treated with Bupivacaine] results in increased expression of BAX protein]; [Glucose co-treated with Bupivacaine] results in increased expression of BAX protein; [Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX mRNA; [Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein modified form; CEBPB protein inhibits the reaction [Glucose results in increased expression of BAX protein]; gastrodin inhibits the reaction [Glucose results in increased expression of BAX protein]; HIF1A protein affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; HIF1A protein affects the reaction [MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]]; Isoflurane inhibits the reaction [2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX mRNA]]; Isoflurane inhibits the reaction [2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]]; Isoflurane inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX mRNA]; Isoflurane inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; MIR186 mRNA inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; SIRT7 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; U 0126 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; Valsartan inhibits the reaction [Glucose results in increased expression of BAX protein]PMID:24682241 PMID:25238743 PMID:28675767 PMID:29266779 PMID:31672611 PMID:33508982 PMID:33759271 PMID:33764184
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; [Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA; [Glucose co-treated with Deferoxamine] results in increased expression of BAX protein; asiatic acid inhibits the reaction [Glucose results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Glucose results in increased expression of BAX mRNA]; diallyl trisulfide inhibits the reaction [Glucose results in increased expression of BAX protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX protein]; MIR142 affects the reaction [TAOK1 mRNA alternative form affects the reaction [Glucose results in increased expression of BAX protein]]; MIR142 inhibits the reaction [Glucose results in increased expression of BAX protein]; MitoTEMPO inhibits the reaction [Glucose results in increased expression of BAX protein]; NDRG2 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; polyethylene glycol loxenatide inhibits the reaction [Glucose results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]; salvianolic acid inhibits the reaction [Glucose results in increased expression of BAX protein]; SOX6 protein inhibits the reaction [MIR142 inhibits the reaction [Glucose results in increased expression of BAX protein]]; spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]; TAOK1 mRNA alternative form affects the reaction [Glucose results in increased expression of BAX protein]PMID:23451161 PMID:24218232 PMID:30431688 PMID:30802477 PMID:31115753 PMID:32602595 PMID:33962019 PMID:37417536 PMID:38124441
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