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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDhydroquinone results in decreased expression of BAX proteinPMID:27515134 PMID:33771647 PMID:33932074 PMID:35561756
Baxincreases expressionISOBax (Mus musculus)6480464CTDhydroquinone results in increased expression of BAX proteinPMID:27606422
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDhydroquinone results in increased expression of BAX proteinPMID:28843007 PMID:35123993 PMID:37148176
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of BAX protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [hydroquinone results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of BAX protein]; [ABT-737 co-treated with hydroquinone] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of BAX protein]; ATF6 protein affects the reaction [hydroquinone results in increased expression of BAX protein]; CDKN2A protein affects the reaction [hydroquinone results in decreased expression of BAX protein]; PARP1 protein inhibits the reaction [hydroquinone results in decreased expression of BAX protein]; Sirolimus promotes the reaction [hydroquinone results in increased expression of BAX protein]PMID:28843007 PMID:33771647 PMID:33932074 PMID:35123993 PMID:37148176
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