GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | decreases expression | EXP | | 6480464 | CTD | Melatonin results in decreased expression of BAX protein | PMID:15964511 | Bax | increases expression | EXP | | 6480464 | CTD | Melatonin results in increased expression of BAX mRNA | PMID:16499559 | Bax | multiple interactions | EXP | | 6480464 | CTD | Melatonin inhibits the reaction [Cisplatin results in increased cleavage of BAX protein]; Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Galactose results in increased expression of BAX protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Indomethacin affects the localization of BAX protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Methionine results in increased expression of BAX protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]] | PMID:15683462 PMID:16213988 PMID:19220725 PMID:20041988 PMID:22526374 PMID:34673010 PMID:35093381 PMID:36006825 PMID:36154502 | Bax | decreases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Melatonin results in decreased expression of BAX protein | PMID:18078454 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Melatonin results in increased expression of BAX protein | PMID:14690559 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Melatonin results in increased expression of BAX mRNA; Melatonin results in increased expression of BAX protein | PMID:33507000 PMID:37755321 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of BAX protein]; Melatonin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Melatonin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Melatonin inhibits the reaction [Glyphosate results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]] | PMID:20964710 PMID:21138475 PMID:23963992 PMID:33159990 PMID:35367536 PMID:35643323 PMID:36421005 PMID:36549428 PMID:37975621 PMID:38008054 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with Melatonin] results in increased expression of BAX protein; [Melatonin co-treated with Tretinoin] results in increased expression of BAX protein; [Tretinoin co-treated with Melatonin] results in increased expression of BAX protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAX protein]; Melatonin inhibits the reaction [BAX protein binds to BAX protein]; Melatonin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BAX protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BAX mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]; Melatonin results in increased activity of and results in increased expression of BAX protein; MIR532 promotes the reaction [Melatonin results in increased expression of BAX protein] | PMID:10965999 PMID:18339127 PMID:19552762 PMID:20333787 PMID:24799992 PMID:31330490 PMID:33507000 PMID:33962019 PMID:36549428 PMID:37755321 PMID:9649124 | | ||||||||||||||||||||||
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