Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDthymoquinone affects the reaction [Ethanol affects the expression of BAX mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; thymoquinone inhibits the reaction [Ethanol results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX mRNA]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]PMID:29085585 PMID:29710533 PMID:30558456 PMID:35437842
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDthymoquinone results in increased expression of BAX proteinPMID:31433961 PMID:34627931
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDthymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]PMID:36193556
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of BAX mRNA; thymoquinone results in increased expression of and affects the localization of BAX proteinPMID:24289642 PMID:29981725
Go Back to source page   Continue to Ontology report