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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationISOBax (Mus musculus)6480464CTDdeoxynivalenol affects the localization of BAX proteinPMID:15976193
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDdeoxynivalenol results in decreased expression of BAX mRNAPMID:22269384
Baxincreases expressionISOBax (Mus musculus)6480464CTDdeoxynivalenol results in increased expression of BAX mRNA; deoxynivalenol results in increased expression of BAX proteinPMID:19410639 PMID:25445755 PMID:35817260
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of BAX mRNA; deoxynivalenol results in increased expression of BAX proteinPMID:17166419 PMID:22269384 PMID:37705238
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCurcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]; deoxynivalenol promotes the reaction [Zearalenone results in increased expression of BAX mRNA]PMID:25445755 PMID:35817260
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX mRNA; [Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX protein; Ascorbic Acid inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]PMID:17166419 PMID:35090964
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