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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arntincreases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of ARNT mRNAPMID:19951702 PMID:23273579
Arntincreases localizationISOARNT (Homo sapiens)6480464CTDMethylcholanthrene results in increased localization of ARNT proteinPMID:21756928
Arntmultiple interactionsISOArnt (Mus musculus)6480464CTDCycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]PMID:20570689
Arntmultiple interactionsISOARNT (Homo sapiens)6480464CTD[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Methylcholanthrene; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [ARNT protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to SORL1 promoter]PMID:11768231 PMID:20348232 PMID:24486526
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