Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2139
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	App
Name:	amyloid beta precursor protein

Acc ID:	CHEBI:16905
Term:	keto-D-fructose 1,6-bisphosphate
Definition:	A ketohexose bisphosphate that is D-fructose substituted by phosphate groups at positions 1 and 6.
Chemical ID:	MESH:C029063

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
App	decreases abundance	ISO	APP (Homo sapiens)	6480464	CTD	APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate	PMID:39172838
App	multiple interactions	ISO	APP (Homo sapiens)	6480464	CTD	PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate]	PMID:39172838
App	multiple interactions	ISO	App (Mus musculus)	6480464	CTD	[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fructose-1,6-diphosphate; IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fructose-1,6-diphosphate]; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fructose-1,6-diphosphate]	PMID:39172838

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