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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:61076
Term: belinostat
Definition: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Chemical ID: MESH:C487081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDbelinostat results in increased cleavage of PARP1 proteinPMID:18223231 PMID:25537862
Parp1increases expressionISOParp1 (Mus musculus)6480464CTDbelinostat results in increased expression of PARP1 mRNA; belinostat results in increased expression of PARP1 proteinPMID:29733868
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDBortezomib promotes the reaction [belinostat results in increased cleavage of PARP1 protein]PMID:18223231
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